| Autor: |
Sarela, A. I., Gallagher, H. J., Macadam, R. C. A., O’Riordain, D. S., Parkin, A., Guillou, P. J. |
| Předmět: |
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| Zdroj: |
Colorectal Disease; Nov2000, Vol. 2 Issue 6, p346-350, 5p |
| Abstrakt: |
Objective The hepatic perfusion index (HPI) is a ratio of the gradient of hepatic arterial to total hepatic blood flow. This study correlated HPI with histopathological indicators of prognosis and disease-free survival following curative resection of colorectal cancer. Patients and methods HPI was measured preoperatively by dynamic hepatic scintigraphy in 37 patients with a primary colorectal cancer and no evidence of distant metastases who underwent a curative resection. Results Abnormally elevated HPI were detected in 49% of patients and were significantly more frequent in association with locally advanced tumours (T3 and T4) in comparison with early tumours (T1 and T2; 59% vs 20%, respectively; P=0.04). There was no association between abnormal HPI and presence of lymph node metastases or degree of tumour differentiation. The 18-month disease-free survival rate of patients with abnormal HPI was significantly shorter than that of patients with normal HPI (53% vs 100%, respectively; P=0.01), and this was independent of the T category. Conclusion HPI predicts the risk of recurrent colorectal carcinoma, and this measurement should be included in the panel of prognostic markers in future clinical trials. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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