Platelet damage and haemolysis during bubble oxygenator perfusion with and without arterial line filter, compared to membrane oxygenator perfusion.

Autor: Boonstra, PW, Vermeulen, Fee, Leusink, JA, de Nooy, EH, van Zalk, A., Soons, Jbj, Wildevuur, Crh
Zdroj: Perfusion; Jan1987, Vol. 2 Issue 1, p27-33, 7p
Abstrakt: We determined to what extent a 27 micron depth filter (Bentley Polyfilter bypass blood filter PF427, Bentley Lab., Irvine, California, USA) in the arterial line of a bubble oxygenator (BO) system is responsible for the difference in haemocompatibility between this BO system and a membrane oxygenator (MO) system in which no arterial line filter is used. We studied three groups of patients subjected to long perfusions of approximately three hours: BO perfusion with (n = 8) and without (n = 8) the arterial line filter and MO perfusion ( n = 10) without filter. Platelet and erythrocyte damage were evaluated at seven sampling points during perfusion. Also pre- and postoperative bleeding times and postoperative blood loss and blood transfusions up to 18 hours after perfusion were determined.We found that the 27 micron depth filter in the arterial line impairs the haemocompatibility of the BO only to a small extent; the MO remains haematologically superior over the BO even when the arterial line filter is absent from the BO circuit. [ABSTRACT FROM PUBLISHER]
Databáze: Complementary Index