Identification and Design of p53-Derived HLA-A2-Binding Peptides with Increased CTL Immunogenicity.

Autor: Petersen, T.R., Buus, S., Brunak, S., Nissen, M.H., Sherman, L.A., Claesson, M.H.
Předmět:
Zdroj: Scandinavian Journal of Immunology; Apr2001, Vol. 53 Issue 4, p357, 7p, 1 Chart, 9 Graphs
Abstrakt: Examines the p53 protein-derived human leucocyte antigen (HLA)-A2-binding peptides with increased cytotic T lymphocyte immunogenicity. Replacement of the natural P2 residue with the optimal leucine residue; Stabilization of HLA-A2 molecules; Efficiency of the modified peptides.
Databáze: Complementary Index