The frequency of early, spontaneous miscarriage associated with the leu33pro polymorphism of Glycoprotein IIIa: A pilot study.

Autor:	LAMBRINOUDAKI, Irene, ARMENI, Eleni, KAPAROS, George J., CHRISTODOULAKOS, George E., SERGENTANIS, Theodor N., ALEXANDROU, Andreas, CREATSA, Maria, KOUSKOUNI, Evangelia
Předmět:	ACADEMIC medical centers ANALYSIS of variance BLOOD diseases CARDIOVASCULAR diseases risk factors CHI-squared test COMPUTER software EPIDEMIOLOGY GENETIC polymorphisms GLYCOPROTEINS EVALUATION of medical care MISCARRIAGE PREGNANCY complications RESEARCH funding STATISTICS T-test (Statistics) PILOT projects THROMBOSIS DATA analysis MULTIPLE regression analysis POSTMENOPAUSE PREGNANCY GENETICS
Zdroj:	Australian & New Zealand Journal of Obstetrics & Gynaecology; Oct2010, Vol. 50 Issue 5, p485-490, 6p, 3 Charts, 1 Graph
Abstrakt:	Background: Inherited thrombophilia is associated with both poor obstetrical outcomes and increased cardiovascular risk later in life. In fact, a personal history of spontaneous miscarriage is reported to increase the risk of subsequent ischaemic heart disease . Aims: This pilot study aims to evaluate the association between genetic polymorphism-related increased risk of arterial thrombosis and the history of spontaneous miscarriage early in pregnancy, among healthy postmenopausal women. Methods: The following polymorphisms were assessed in 84 healthy post-menopausal women: Glycoprotein IIIa leu33pro, Apolipoprotein E2/E3/E4, Methylenetetrahydrofolate reductase, Apolipoprotein B arg3500gln, Paraoxonase 1 gln182arg, Plasminogen activator inhibitor 1 4G/5G, Cholesterol-7α-hydroxylase and Cholesterol ester transfer protein (ΤaqIB) B1/B2. The association between the polymorphisms and history of spontaneous pregnancy loss was evaluated. Results: The frequency of the PLA2 allele of glycoprotein IIIa was significantly higher in women who experienced spontaneous miscarriage when compared with controls ( P = 0.033). Glycoprotein IIIa leu33pro polymorphism correlated positively with the frequency of spontaneous miscarriage ( P = 0.027). Among women reporting miscarriage, 55.6% were heterozygous compared with 44.4% who were wild type. We found no significant association between any of the other polymorphisms and spontaneous pregnancy loss. Conclusions: Our findings indicate that Glycoprotein IIIa leu33pro polymorphism is associated with early, spontaneous miscarriage. The causative role of this polymorphism as a risk factor of pregnancy loss needs further investigation by prospective studies. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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