Phosphonate quinoxalinedione AMPA antagonists.

Autor: Turski, Lechoslaw, Schneider, Herbert H., Neuhaus, Roland, McDonald, Fiona, Jones, Graham H., Löfberg, Boel, Schweinfurth, Hermann, Huth, Andreas, Kr¨ger, Martin, Ottow, Eckhard
Předmět:
Zdroj: Restorative Neurology & Neuroscience; 2000, Vol. 17 Issue 1, p45, 16p
Abstrakt: Presents a study to determine the effectiveness of glutamate antagonists derived from the quinoxalinedione scaffold, with the introduction of a phosphonate group, as a neuroprotective treatment for stroke and head and spinal cord trauma. Methods; Results; Conclusion that phosphonate quinoxalinedione derivatives ZK202000 and ZK200775 protected rodent brain against sequelae of premanent occlusion of the middle cerebral artery and head trauma.
Databáze: Complementary Index