| Autor: |
Ryzhova, E. S., Panteleev, D. A., Chudetskaya, Yu. V., Volkov, A. A., Mel'nikova, N. B., Gulenova, M. V., Osmanov, V. K., Borisov, A. V. |
| Předmět: |
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| Zdroj: |
Pharmaceutical Chemistry Journal; Apr2010, Vol. 44 Issue 4, p205-212, 8p, 1 Diagram, 3 Charts, 6 Graphs |
| Abstrakt: |
The effect of tautomerism on the structure of products from the reaction of N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5 H-pyrimidinesulfone)- N′-isonicotinoylhydrazide (kristafon) with acids (hydrochloric, phosphoric, acetic, oxalic, succinic, citric, hyaluronic) and bases [sodium hydroxide, triethanolamine, tris-(hydroxymethyl)aminomethane] in aqueous media has been studied using UV, IR, PMR, and C NMR spectroscopy techniques. The properties of kristafon are compared to those of analogous compounds containing pyridine (isonicotine hydrazide, sulfotolylisonicotine hydrazide) and pyrimidine [ bis- p-(2,4-dioxo-6-methylpyrimidinyl-5-sulfonamino)-diphenylsulfone] fragments in acid-base media. It is shown that the immunotropic activity of kristafon phosphate and kristafon are improved in hyaluronic acid solution. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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