| Autor: |
Largent, Joan, Bernstein, Leslie, Horn-Ross, Pamela, Marshall, Sarah, Neuhausen, Susan, Reynolds, Peggy, Ursin, Giske, Zell, Jason, Ziogas, Argyrios, Anton-Culver, Hoda, Largent, Joan A, Horn-Ross, Pamela L, Marshall, Sarah F, Zell, Jason A |
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| Zdroj: |
Cancer Causes & Control; Oct2010, Vol. 21 Issue 10, p1615-1624, 10p, 4 Charts |
| Abstrakt: |
Background: We investigated the association between hypertension, antihypertensive (AH) medication use, and breast cancer in a large prospective study, the California Teachers Study (CTS).Methods: Information on history of hypertension and lifetime regular use of AH medications was collected from 114,549 women in 1995-1996. Among them, 4,151 invasive breast cancers were diagnosed between 1995 and 2006. Additional information on AH use was collected from 73,742 women in 2000-2001, and 1,714 of these women were subsequently diagnosed with breast cancer. Cox proportional hazards regression was used to estimate relative risks (RR) and 95% confidence intervals (CI) for breast cancer.Results: Use of AH medication for ≥5 years, when compared with no use, was associated with a modest increased risk of invasive breast cancer (RR = 1.18, 95%CI 1.02-1.36). This increased risk appeared to be confined to estrogen receptor (ER)-positive tumors (RR = 1.21, 95%CI 1.03-1.43) and pre-/peri-menopausal women (RR = 1.58, 95%CI 1.11-2.25).Conclusions: Increased risk of invasive breast cancer was observed for long-term (≥5 years) AH use, and this appeared to be confined to ER + breast cancer and younger women. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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