| Autor: |
Kodama, Yasuo, Kodama, Hirofumi, Kuranari, Masae, Tsutsumi, Kimiko, Ono, Shunsuke, Fujimura, Akio |
| Zdroj: |
Journal of Clinical Pharmacology; Oct1999, Vol. 39 Issue 10, p1070-1076, 7p |
| Abstrakt: |
The gender and age related binding characteristics of valproic acid to serum proteins were determined in the pediatric population. Serum samples examined in the study were obtained from 61 pediatric patients (28 males, 33 females) with epilepsy on valproic acid monotherapy. Their ages ranged from 1 to 15 years (mean age with [SD]: 7.8 [3.9] years; < 10 years, n= 41;310 years, n= 20). The in vivo population binding parameters of valproic acid to serum proteins and theoretical minimal unbound serum fraction (fu) of valproic acid were determined in (1) all, (2) male and female subgroups, and (3) prepubescent (< 10 years) and pubescent (310 years) subgroups. The association constant (K) was approximately 1.4 times higher in male (0.018 L/mmol) than in female (0.013 L/mmol) patients, while the total concentration of binding sites (n(Pt)) was 1.2 times greater in female (1235mmol/L) than in male (997mmol/L) patients. The fuwas 0.053 and 0.059 for male and female patients, respectively. The value ofKwas approximately 1.6 times higher in the pubescent (0.019 L/mmol) than in the prepubescent (0.012 L/mmol) patients, while the n(Pt) was 1.2 times higher in the prepubes cent (1244mmol/L) than in the pubescent (1057mmol/L) patients. The fuwas 0.063 for the prepubescent and 0.047 for the pubescent patients. No significant differences were observed in binding characteristics of valproic acid to serum proteins between male and female or younger and older patients. However, the differences in valproic acid binding to serum proteins appear to be relatively larger in binding affinity than in binding capacity between the two groups. Because no significant differences were observed in serum concentrations of total and unbound valproic acid, albumin, or free fatty acids between any subgroups (male and female, younger and older), the results suggest that gender or age may not be factors for the determination of the binding characteristics of valproic acid to serum proteins in pediatric patients. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
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