| Autor: |
Andersen, Scott R., Lambrecht, Lawrence J., Swan, Suzanne K., Cutler, David L., Radwanski, Elaine, Affrime, Melton B., Garaud, Jean-Jacques |
| Zdroj: |
Journal of Clinical Pharmacology; Oct1999, Vol. 39 Issue 10, p1015-1020, 6p |
| Abstrakt: |
The pharmacokinetics of intravenously administered recombinant human interleukin-10 (rHuIL-10) were evaluated in 18 subjects with creatinine clearances (Clcr) between 2.7 and 116.7 mL/min/1.73m2. Serum samples for rHuIL-10 were obtained over a 48-hour period after a single 25mg/kg IV bolus infusion. AUC, total body clearance (Clp), and steady-state volume of distribution (Vdss) were derived by compartmental methods. Analysis of serum concentrations showed statistically significant group differences for log-transformed AUC and original scale Clp (p< 0.01). The AUC and effective half-life increased, while the mean Clp of rHuIL-10 decreased as renal function declined. A linear relationship between AUC and Clcr as well as Clp and Clcr demonstrates that the disposition of rHuIL-10 is altered in subjects with renal insufficiency. No serious adverse events were noted. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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