| Autor: |
Briggs, William A., Eustace, Joseph, Gimenez, Luis F., Choi, Michael J., Scheel, Paul J., Burdick, James F. |
| Zdroj: |
Journal of Clinical Pharmacology; Feb1999, Vol. 39 Issue 2, p125-130, 6p |
| Abstrakt: |
Methyl prednisolone has been found to be sig nificantly more suppressive than prednisolone (the pharmacologically active metabo lite of predni sone) of mitogen-stimulated humanlym-phocyte proliferation. In this study, peripheral blood mononuclear cells (PBMC) from end stage renal dis ease patients were cultured with phytohemagglutinin (PHA) alone and with methyl prednisolone and prednisolone individually, as well as eachglucocorticoid (10−7 mol/L) in com bination with 300 ng/ml cyclo spor ine, 10 ng/ml tac ro limus, 25 mg/ml pentoxifylline, and 10−7 mol/L myco phenolicacid. Under each experimental condition, the mean ± SD% inhibition of PHA-stimulated 3H-thymidine incor poration was sig nificantly greater with methyl prednisolone than with prednisolone: methylprednisolone 55 ± 17 versus prednisolone 28 ± 14, p < 0.001; methyl prednisolone + cyclo sporine 76 ± 18 versus prednisolone + cyclosporine 52 ± 18, p < 0.001; methyl - prednisolone + tacrolimus 74 ± 18 versus prednisolone + tacrolimus 50 ± 20, p = 0.001; methyl prednisolone + mycophenolic acid 69 ± 14 versus prednisolone + mycophenolic acid 46 ± 15, p < 0.001. These results confirm and extend previous obser vations and sug gest that methyl prednisolone might be more effective than prednisone in treatment protocols used to sup press allograft rejection. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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