| Autor: |
Séréni, Daniel, Tubiana, Roland, Lascoux, Caroline, Katlama, Christine, Taulera, Oliver, Bourque, Andre, Cohen, Aharon, Dvorchik, Barry, Martin, R. Russell, Tournerie, Christophe, Gouyette, Alain, Schechter, Paul J. |
| Zdroj: |
Journal of Clinical Pharmacology; Jan1999, Vol. 39 Issue 1, p47-54, 8p |
| Abstrakt: |
Trecovirsen, a 25-mer antisense phosphorothioate oligonucleotide targeted at the gag site of the HIV gene, was administered to HIV-positive volunteers as an IV infusion. Single doses ranged from 0.1 to 2.5 mg/kg in an ascending escalation in cohorts of 6 to 12 subjects. Plasma trecovirsen concentrations and pharmacokinetic parameters could be assessed at doses ≥0.3 mg/kg. Peak plasma concentrations and AUC values increased disproportionately with increasing dose while elimination half-life increased and plasma clearance decreased, indicating a saturable process over this dose range. The only significant adverse event observed was an isolated, transitory increase in activated partial thromboplastin time at doses ≥ 2.0 mg/kg that was related to plasmatre covirsen concentrations and is attributed to the polyanionic character of the molecule. Thus, trecovirsen administration was well tolerated in single IV doses up to 2.5 mg/kg. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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