| Autor: |
Ohta, Toshiyuki, Kawaguchi, Hiroshi, Hattori, Motoshi, Takahashi, Kazuhiro, Nagafuchi, Hiroyuki, Akioka, Yuko, Mizushima, Waichiro, Ishikawa, Nobuo, Tanabe, Kazanari, Toma, Hiroshi, Takahashi, Kota, Ota, Kazuo, Ito, Katsumi |
| Předmět: |
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| Zdroj: |
Pediatric Nephrology; Jan2000, Vol. 14 Issue 1, p1-5, 5p |
| Abstrakt: |
We have performed ten pediatric kidney transplantations from living-related ABO-incompatible donors. All patients underwent preoperative plasmapheresis with or without immunoadsorption to reduce isoagglutinin. Primary immunosuppression consisted of methylprednisolone, cyclosporin or tacrolimus, azathioprine, anti-lymphocyte globulin, and/or deoxyspergualin. At transplantation splenectomy was simultaneously performed in all patients. Median follow-up is 65 months (range 4–95 months). The patient and graft survival rates are 100% to date. Post-transplantation isoagglutinin titers did not increase more than 1:32, except for 1 patient, without uncontrollable vascular rejection episodes. Despite the heavy immunosuppressive regimen, cytomegalovirus infection occurred in only three patients, who were successfully treated with ganciclovir and cytomegalovirus high-titer gamma globulin. Our small series clearly shows that the preoperative reduction of isoagglutinin, splenectomy, and strict immunosuppressive therapy lead to successful long-term results in children. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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