| Autor: |
Kresnik, E., Mikosch, P., Gallowitsch, H.J., Kogler, D., Wieser, S., Heinisch, M., Unterweger, O., Raunik, W., Kumnig, G., Gomez, I., Grünbacher, G., Lind, P. |
| Předmět: |
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| Zdroj: |
European Journal of Nuclear Medicine; 2001, Vol. 28 Issue 7, p816, 6p |
| Abstrakt: |
The aim of this study was to evaluate the usefulness of [sup 18] F-FDG PET in the diagnosis and staging of primary and recurrent malignant head and neck tumours in comparison with conventional imaging methods [including ultrasonography, radiography, computed tomography (CT) and magnetic resonance imaging (MRI)], physical examination, panendoscopy and biopsies in clinical routine. A total of 54 patients (13 female, 41 male, age 61.3±12 years) were investigated retrospectively. Three groups were formed. In group I, [sup 18] F-FDG PET was performed in 15 patients to detect unknown primary cancers. In group II, 24 studies were obtained for preoperative staging of proven head and neck cancer. In group III, [sup 18] F-FDG PET was used in 15 patients to monitor tumour recurrence after radiotherapy and/or chemotherapy. In all patients, imaging was obtained at 70 min after the intravenous administration of 180 MBq [sup 18] F-FDG. In 11 of the 15 patients in group I, the primary cancer could be found with [sup 18] F-FDG, yielding a detection rate of 73.3%. In 4 of the 15 patients, CT findings were also suggestive of the primary cancer but were nonetheless equivocal. In these patients, [sup 18] F-FDG showed increased [sup 18] F-FDG uptake by the primary tumour, which was confirmed by histology. One patient had recurrence of breast carcinoma that could not be detected with [sup 18] F-FDG PET, but was detected by CT. In three cases, the primary cancer could not be found with any imaging method. Among the 24 patients in group II investigated for staging purposes, [sup 18] F-FDG PET detected a total of 13 local and three distant lymph node metastases, whereas the conventional imaging methods detected only nine local and one distant lymph node metastases. The results of [sup 18] F-FDG PET led to an upstaging in 5/24 (20.8%) patients. The conventional imaging methods were false positive in 5/24 (20.8%). There was one false positive result using [sup 18] F-FDG PET.... [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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