| Autor: |
Uglanova, S., Popov, M., Kurova, V., Batrakova, E., Manickam, D., Kabanov, A., Klyachko, N. |
| Zdroj: |
Moscow University Chemistry Bulletin; Jun2010, Vol. 65 Issue 3, p190-196, 7p |
| Abstrakt: |
Nanosized particles with a radius of 16 ± 2 nm based on complexes and conjugates of highly active superoxide dismutase and catalase with polyelectrolyte block copolymer poly(ethyleneimine)-poly(ethylene glycol) and similar bienzyme systems were obtained. Mass spectrometry was used to confirm the crosslinking of enzyme and block copolymer molecules in the nanoparticles that were formed. A significant increase of SOD and catalase stability (up to four times) towards proteolytic degradation under chymotrypsin and trypsin action for 3 h at 37°C was revealed when enzyme-containing nanoparticles were used for experiments. Antioxidant enzymes-containing polyelectrolyte nanoparticles seem to be promising for BBB penetration and CNS drug delivery. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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