| Autor: |
Benko, Rita, Molnár, Zsuzsanna, Nemes, Dániel, Dékány, András, Kelemen, Dezsö, Illényi, Lászlo, Cseke, Lászlo, Papp, András, Varga, Gábor, Bartho, Loránd |
| Předmět: |
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| Zdroj: |
Pharmacology; 2010, Vol. 86 Issue 3, p145-148, 4p, 3 Graphs |
| Abstrakt: |
Background/Aims: Morphine is known to inhibit cholinergic contractions of the guinea pig small intestine. This has been compared to the human small intestinal innervated longitudinal muscle in the current study. Methods: Cholinergic primary contractions of human small intestinal longitudinal strips were evoked by electrical field stimulation (EFS; 0.5– 5 Hz in the presence of purinergic and nitrergic blockers or 5 Hz without pretreatment) and recorded isotonically in organ bath experiments. Guinea pig small intestinal segments were also studied. Results and Conclusion: Neurogenic cholinergic contractions of human preparations were unaffected by morphine (1, 2 or 10 μmol/l). Longitudinal contractions of the guinea pig ileum were concentration-dependently suppressed by morphine (0.1–10 μmol/l). It is concluded that myenteric neurons supplying the longitudinal muscle of the human small intestine are much less sensitive to morphine than those of the guinea pig. Copyright © 2010 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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