| Autor: |
Yingchun Zhang, Bicek, Andrew D., Guangjian Wang, Timm, Gerald W. |
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| Zdroj: |
International Urogynecology Journal; Oct2010, Vol. 21 Issue 10, p1279-1284, 6p |
| Abstrakt: |
Introduction and hypothesis: This study aims to test the hypothesis that a urethra-to-bladder inhibitory pathway exists through which periurethral neuromuscular electrical stimulation (NMES) inhibits overactive bladder contractions in rats. Methods: Bladder overactivity was induced in 22 female Sprague Dawley rats by injection of ketamine/xylazine/acepromizine (K/X/A). A bipolar electrode was placed surgically in the periurethral region to deliver NMES. Intravesical pressure, bladder inter-contraction interval (ICI) and voided volume (VV) were monitored while the bladder was continuously infused with saline. Results: K/X/A induced more frequent bladder contractions (ICI = 48.6 ± 20.1 s, before cutting the pubo-symphasis) compared to a 10-min ICI induced by urethane. NMES significantly increased ICI (63.1 ± 31.3 s before vs. 97.2 ± 42.9 s after NMES, p < 0.001) and VV (0.063 = 0.041 ml before vs. 0.088 = 0.044 ml after NMES, p < 0.02). Conclusions: Injection of K/X/A may potentially be used as a model of bladder overactivity. NMES inhibits bladder contractions in rats with bladder overactivity, which supports the existence of a urethra-to-bladder inhibitory pathway. [ABSTRACT FROM AUTHOR] |
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