| Autor: |
Jenkins, M. W., Duke, A. R., Gu, S., Doughman, Y., Chiel, H. J., Fujioka, H., Watanabe, M., Jansen, E. D., Rollins, A. M. |
| Předmět: |
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| Zdroj: |
Nature Photonics; Sep2010, Vol. 4 Issue 9, p623-626, 4p, 1 Color Photograph, 1 Black and White Photograph, 2 Graphs |
| Abstrakt: |
Light has been used to non-invasively alter the excitability of both neural and cardiac tissue. Recently, pulsed laser light has been shown to be capable of eliciting action potentials in peripheral nerves and in cultured cardiomyocytes. Here, for the first time, we demonstrate optical pacing of an intact heart in vivo. Pulsed 1.875-µm infrared laser light was used to lock the heart rate to the pulse frequency of the laser. A laser Doppler velocimetry signal was used to verify the pacing. At low radiant exposures, embryonic quail hearts were reliably paced in vivo without detectable damage to the tissue, indicating that optical pacing has great potential as a tool with which to study embryonic cardiac dynamics and development. In particular, optical pacing can be used to control the heart rate, thereby altering stresses and mechanically transduced signalling. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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