| Autor: |
Hara, Hidehiko, Nakamura, Masato, Yokouchi, Itaru, Kimura, Keiko, Nemoto, Naohiko, Ito, Shingo, Ono, Tsuyoshi, Itaya, Hideki, Shiba, Masanori, Wada, Masamichi, Iijima, Raisuke, Yamamoto, Masaya, Yamamoto, Masato, Hara, Hisao, Takagi, Takuro, Asahara, Toshiyuki, Mitsuo, Kazuhisa, Kobayashi, Nobuyuki, Sugi, Kaoru |
| Zdroj: |
Therapeutic Advances in Cardiovascular Disease; Oct2009, Vol. 3 Issue 5, p357-365, 9p |
| Abstrakt: |
Background: While preprocedural statin treatment for acute coronary syndrome (ACS) is widely regarded as beneficial, there has been no prospective randomized multicenter trial of patients with non-ST elevation ACS in the Japanese population to examine the efficacy of preprocedural aggressive statin use. The aim of this study was to confirm this effect by prospective randomized multicenter design.Methods: Fifty patients who presented with non-ST elevation ACS were enrolled, and randomly assigned to aggressive statin administration before percutaneous coronary intervention (PCI). Troponin-T (TnT), creatine phosphokinase (CK), CK-myocardial band (CK-MB), high-sense C-reactive protein (hs-CRP), and brain natriuretic peptide (BNP) were measured at baseline and/ or after procedure.Results: Three days after PCI, the statin group had significantly less CK elevation compared with the nonstatin group (84±17 IU/l versus 180±68 IU/l, respectively, p = 0.02). CK-MB elevation also tended to be lower in the statin group than in the nonstatin group (3.2±1.9 versus. 7.0±3.0, respectively, p = 0.07), as was BNP level (3.2±1.9 versus 7.0±3.0 pg/ml, respectively, p = 0.07). The change of serum LDL cholesterol was significantly correlated with CK (p = 0.01) and TnT (p = 0.02) at 1 day after PCI.Conclusions: Aggressive statin usage before PCI to Japanese patients with non-ST elevation ACS appears to reduce myocardial damage after procedure. The degree of serum lipid level reduction may reflect the vulnerability of atheromatous plaques that could cause cardiac damage after PCI. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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