| Autor: |
Dushay, Mitchell S., Rosbash, Michael, Hall, Jeffrey C. |
| Zdroj: |
Journal of Biological Rhythms; Mar1989, Vol. 4 Issue 1, p1-27, 27p |
| Abstrakt: |
Mutations at the disconnected (disco) locus in Drosophila melanogaster cause cultures of this insect to eclose in an essentially arrhythmic manner and also nearly eliminate free-running circadian rhythms of locomotor activity. Yet disco mutants are not totally light- insensitive : Whereas they performed very poorly in tests of certain behavioral responses to visual stimuli, they were able to exhibit "forced" periodic locomotor activity under conditions of light-dark cycling. We discuss these results in the context of (1) the dispensability of this insect's external photoreceptors for entrainment of its circadian pacemaker, and (2) possible disco-induced abnormalities in the connections of extraocular photoreceptors to their targets in the central nervous system and/or abnormalities in the targets themselves—which presum ably include elements of the fly's circadian clock. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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