Targeted Delivery of Drugs Provided by Water-Soluble Polymeric Systems with Low Critical Solution Temperature (LCST.

Autor: Valuev, Lev I., Zefirova, Olga N., Obydennova, Irina V., Plate, Nikolai A.
Zdroj: Journal of Bioactive & Compatible Polymers; Jan1994, Vol. 9 Issue 1, p55-65, 11p
Abstrakt: A new approach to the targeted thermally activated transport of chemical agents and physiologically active compounds is reported. The method involves the immobilization of these compounds on a water-soluble polymer with a low critical solution temperature and heating the delivery site above the critical temperature. The approach was illustrated with trypsin immobilized on N-isopropylacrylamide-acrylamide-N-acryloylphthalimide ternary copoly mers. [ABSTRACT FROM PUBLISHER]
Databáze: Complementary Index