| Autor: |
Deyme, M., Spenlehauer, G., Benoit, J.-P. |
| Zdroj: |
Journal of Bioactive & Compatible Polymers; Apr1992, Vol. 7 Issue 2, p149-160, 12p |
| Abstrakt: |
The dissolution kinetics, in an aqueous medium, of a water solu ble drug dispersed in an insoluble polymeric matrix, depends highly on the drug loading. A computer model of cisplatin loaded poly(lactide-co-glycolide) microspheres dissolution confirms the hypothesis that only the drug crystals connected to the surface of the microspheres are capable of dissolving through a site percolation mechanism. This behavior may also be possible with other drug release systems, limiting their use for controlled release. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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