Response to cladribine in previously treated patients with chronic lymphocytic leukaemia identified by ex vivo assessment of drug sensitivity by DiSC assay.

Autor: Bosanquet, Andrew G., Copplestone, J. Adrian, Johnson, Stephen A. N., Smith, Alastair G., Povey, Sara J., Orchard, Jennifer A., Oscier, David G., Bosanquet
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Zdroj: British Journal of Haematology; Aug99, Vol. 106 Issue 2, p474-476, 3p, 2 Graphs
Abstrakt: The ability to identify non-responders to cytotoxic chemotherapy has significant clinical and economic benefits. Differential staining cytotoxicity (DiSC) assays were performed in 34 previously treated patients with chronic lymphocytic leukaemia prior to treatment with cladribine. Of the 28 identified as ex vivo sensitive, 26 achieved a complete (CR) or partial response (PR) (median length of response 1.5 years, median survival 3.37 years) and two had a >70% fall in lymphocytes: six identified as ex vivo resistant failed to respond. The DiSC assay can accurately identify a subgroup of patients resistant to cladribine. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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