| Autor: |
Gandhi, Roopali, Kumar, Deepak, Burns, Evan J., Nadeau, Meghan, Dake, Ben, Laroni, Alice, Kozoriz, Deneen, Weiner, Howard L., Quintana, Francisco J. |
| Předmět: |
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| Zdroj: |
Nature Immunology; Sep2010, Vol. 11 Issue 9, p846-853, 8p, 8 Graphs |
| Abstrakt: |
The aryl hydrocarbon receptor (AhR) participates in the differentiation of mouse regulatory T cells (Treg cells) and interleukin 17 (IL-17)-producing helper T cells (TH17 cells), but its role in human T cell differentiation is unknown. We investigated the role of AhR in the differentiation of human induced Treg cells (iTreg cells). We found that AhR activation promoted the differentiation of CD4+Foxp3− T cells, which produce IL-10 and control responder T cells through granzyme B. However, activation of AhR in the presence of transforming growth factor-β1 induced Foxp3+ iTreg cells, which suppress responder T cells through the ectonucleoside triphosphate diphosphohydrolase CD39. The induction of functional Foxp3+ iTreg cells required coordinated action of the transcriptional regulators Smad1 and Aiolos. Thus, AhR is a potential target through which functional iTreg cells could be induced in human autoimmune disorders. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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