| Autor: |
Ibrahim, I. T., Motaleb, M. A., Attalah, K. M. |
| Předmět: |
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| Zdroj: |
Journal of Radioanalytical & Nuclear Chemistry; Sep2010, Vol. 285 Issue 3, p431-436, 6p, 1 Chart, 8 Graphs |
| Abstrakt: |
The optimization of the radiolabeling yield of ciprofloxacin analogous, norfloxacin, with technetium-99m (Tc) was described. Dependence of the labeling yield of Tc–norfloxacin complex on the concentration of norfloxacin, SnCl·2HO content, pH of the reaction mixture and reaction time was studied. Norfloxacin was labeled with Tc at pH 3 with a labeling yield of 95.4% by using 5 mg norfloxacin, 50 μg SnCl·2HO and 30 min reaction time. The formed Tc–norfloxacin complex was stable for a time up to 3 h. Biological distribution of Tc–norfloxacin complex was investigated in experimentally induced inflammation rats using Staphylococcus aureus (bacterial infection model) and heat killed Staphylococcus aureus and turpentine oil (sterile inflammation model). In case of bacterial infection, the T/NT value for Tc–norfloxacin complex was found to be 6.9 ± 0.4 which was higher than that of the commercially available Tc–ciprofloxacin under the same experimental condition. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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