| Autor: |
Macedo, J., Macedo, C., Elkis, H., De Oliveira, I., Reis de Oliveira, Irismar |
| Předmět: |
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| Zdroj: |
Journal of Clinical Pharmacy & Therapeutics; Oct98, Vol. 23 Issue 5, p345-352, 08p |
| Abstrakt: |
Objective: The purpose of this study was to compare the effect of three groups of anti-resorptive drugs in post-menopausal osteoporosis. Data sources: We collected data covering the period between 1983 and 1995, by first using MEDLINE. References retrieved were scanned further to identify additional papers. Study selection: Only randomized studies evaluating bone mass by means of dual-photon or dual energy densitometry over a period of 1 year were accepted. Data extraction: Studies were arranged into three drug groups. We used densitometry results after 1 year in all treatment or control groups. Factors which might interfere with the results were recorded for subsequent separate analysis. Data synthesis: The MEDLINE search identified almost 25,000 studies. On reading the abstracts, 275 trials appeared to be controlled trials and original copies were retrieved for detailed analysis. A total of 31 articles which satisfied the inclusion criteria were identified. The first meta-analysis included studies which compared oestrogens and placebo, and the global effect-size was 0·54 (95% CI 0·34, 0·73). The second meta-analysis compared calcitonins with placebo and produced an effect-size of 0·41 (95% CI 0·21, 0·61) The third analysis compared bisphosphonates and placebo and showed an effect-size of 0·87 (95% CI 0·68, 1·07). Only oestrogen dose affected the results found. Conclusions: BisIphosphonates had the greatest effect on bone mass in post-menopausal osteoporosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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