Autor: |
Oparaoji, E., Siram, S., Shoheiber, O., Cornwell III, E., Mezghebe, H. |
Předmět: |
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Zdroj: |
Journal of Clinical Pharmacy & Therapeutics; Jun98, Vol. 23 Issue 3, p185-190, 06p |
Abstrakt: |
Objective: To determine the frequency with which early adequate peak serum concentrations (6–12 mg/litre) can be achieved following a 4 mg/kg loading dose of gentamicin or tobramycin in post-operative septic shock patients. Method: Eleven post-operative septic shock patients were grouped into (i) a control group (n=7) who received the conventionl gentamicin or tobramycin dosing regimen of 2 mg/kg loading dose followed by a maintenance dose of approximately 1·5 mg/kg (peak and trough levels were measured after the third dose), and (ii) a study group (n=4) who received a tobramycin or gentamicin 4 mg/kg loading dose, followed by 30 min, 3 h and 16 h serum drug level measurements. Pharmacokinetic parameters were calculated using a one-compartmental model. Differences in both groups were determined using Student's t-test. Results: Pharmacokinetic parameters in both groups showed no statistically significant difference. The dose from which peak levels were drawn was significantly higher in the study group (4 mg/kg vs. 1·66 mg/kg; P=0·001), which also resulted in higher but adequate peak serum concentrations (8·9±2·2 vs. 4·8±1·8 mg/litre). In the study group, linear regression analysis showed significant relationships between dose and peak concentrations and volume of distribution and peak concentrations (r=0·96, P=0·01 and r=-0·96, P=0·01, respectively). Conclusion: One hundred per cent of the post-operative septic shock patients achieved target peak serum concentrations (mean 8·9±2·2 mg/litre) following a 4 mg/kg tobramycin or gentamicin loading dose. An expanded Vd (0·46±0·13 litres/kg) was also observed. [ABSTRACT FROM AUTHOR] |
Databáze: |
Complementary Index |
Externí odkaz: |
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