| Autor: |
Morris, C. D., Byrne, J. P., Armstrong, G. R. A., Attwood, S. E. A. |
| Předmět: |
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| Zdroj: |
British Journal of Surgery; Oct2001, Vol. 88 Issue 10, p1357-1362, 6p |
| Abstrakt: |
Background: Patients with Barrett's oesophagus have a risk of approximately 1 per 100 patient-years for the development of oesophageal adenocarcinoma. Endoscopic ablation of Barrett's oesophagus has been shown to lead to the regrowth of a ‘neo’ squamous epithelium if gastro-oesophageal reflux is controlled, but the incidence of subsequent tumour formation is unknown. Methods: The follow-up of 55 patients who underwent endoscopic ablation of Barrett's oesophagus by argon beam plasma coagulation (ABPC) is reported. Of the 55 patients, nine had low-grade dysplasia, nine had high-grade dysplasia and the remainder had non-dysplastic Barrett's metaplasia. Twelve patients had reflux control by antireflux surgery and the remainder received proton pump inhibitor therapy. Barrett's metaplasia was ablated by ABPC to within 2 cm of the gastro-oesophageal junction. Results: To date, one patient has died and one patient was unable to complete treatment. The remaining patients were followed by regular endoscopic surveillance for a mean of 38·5 months to give a total follow-up of 173·5 patient-years. No malignancy has developed in any patient during follow-up. Conclusion: The absence of malignant complications in this study of prophylactic ablation of long-segment Barrett's oesophagus strengthens the argument for endoscopic ablation in the prevention of oesophageal adenocarcinoma. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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