| Autor: |
Federico, Giovanni, Tumbarello, Mario, Spanu, Teresa, Roselli, Romeo, Iacoangeli, Maurizio, Scerrati, Massimo, Tacconelli, Evelina |
| Předmět: |
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| Zdroj: |
Scandinavian Journal of Infectious Diseases; Jul2001, Vol. 33 Issue 7, p533-537, 5p, 3 Charts |
| Abstrakt: |
In order to identify the incidence, risk factors and prognostic indicators of postneurosurgical bacterial meningitis, a 9-y retrospective cohort study was performed. The cohort comprised 3580 individuals who underwent neurosurgical operations at the Department of Neurosurgery of Catholic University, Rome, a 1700-bed university hospital. We observed 52 episodes of postneurosurgical meningitis, with infection rates of 1.4/100 patients, 0.8/100 operations for craniotomies and 2.6/100 operations for internal cerebrospinal fluid (CSF) shunt or ventriculostomy with external drainage. The overall infection rate decreased from 2.5/100 operations in 1989 to 0.9/100 in 1997 (p = 0.03). Logistic regression analysis indicated that duration of ventriculostomy with external drainage [p < 0.01; odds ratio (OR) = 9.67; 95% confidence interval (CI) = 2.44-38.32] and increasing value of the APACHE III score (p < 0.01; OR = 8.51; 95% CI = 2.15-33.68) were independent risk factors for development of meningitis. The overall case fatality rate was 8%. Predictors of mortality were low ( < 1.66 mmol/l) CSF glucose concentration (p = 0.001), increasing value of the APACHE III score (p = 0.002) and Gram-negative aetiology (p = 0.003). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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