Forced degradation of Fas inhibits apoptosis in adenovirus-infected cells.

Autor: Tollefson, Ann E., Hermiston, Terry W., Lichtenstein, Drew L., Colle, Clarence F., Tripp, Ralph A., Dimitrov, Todor, Toth, Karoly, Wells, Christopher E., Doherty, Peter C., Wold, William S. M.
Předmět:
Zdroj: Nature; 4/16/1998, Vol. 392 Issue 6677, p726, 5p, 4 Color Photographs, 17 Black and White Photographs, 1 Chart, 7 Graphs
Abstrakt: Presents research which showed that the adenovirus RID protein complex mediates internalization of cell-surface Fas and its destruction inside lysosomes within the cell. Overcoming host antiviral defenses in DNA viruses; Inhibition of apoptosis in adenovirus-infected cells; Occupation of the cell-surface receptor Fas triggering apoptosis; Other roles for RID; Impact of Fas removal.
Databáze: Complementary Index