Alpha 1 antichymotrypsin is aberrantly expressed during melanoma progression and predicts poor survival for patients with metastatic melanoma.

Autor: Yang Wang, Helen Jiang, Derek Dai, Mingwan Su, Martinka, Magdalene, Brasher, Penny, Yaohua Zhang, McLean, David, Junling Zhang, Wency Ip, Gang Li, Xuejun Zhang, Youwen Zhou
Předmět:
Zdroj: Pigment Cell & Melanoma Research; Aug2010, Vol. 23 Issue 4, p575-586, 12p, 2 Diagrams, 1 Graph
Abstrakt: The article discusses a research study on the clinical significance of serine protease inhibitor alpha 1 antichymotrypsin (ACT) expression during metastatic melanoma (MM) progression. Immunohistochemistry analysis was used to analyze the correlation between ACT protein levels and clinical phenotypes of patients with MM. Details of ACT expression in both benign and malignant melanocytic tumors are explained. It is concluded that ACT may be considered as an independent prognostic marker for MM.
Databáze: Complementary Index