| Autor: |
Granik, V., Grigor"ev, N. |
| Zdroj: |
Russian Chemical Bulletin; Aug2002, Vol. 51 Issue 8, p1375-1422, 48p |
| Abstrakt: |
The review considers problems related to the formation, in the living organism, of nitric oxide, a versatile and vitally important regulator of cell metabolism. The pathways of formation of endogenous nitric oxide from L-arginine are discussed and the main approaches to increasing the NO concentration by introducing various types of exogenous nitric oxide donors into the organism and chemical and biological characteristics of these donors are considered. Primary attention is devoted to the known drugs that were shown to release NO under hydrolytic, oxidative, or reductive conditions. The solution of problems related to the elucidation of the mechanisms of drug action requires that the formation of nitric oxide be taken into account. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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