| Autor: |
Abu, Jeffrey, Hassan, J Abu, Saadiah, S, Roslan, H, Zainudin, Bmz |
| Předmět: |
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| Zdroj: |
Respirology; Dec99, Vol. 4 Issue 4, p423-426, 4p |
| Abstrakt: |
Objective:An increase in incidence of reversible airflow obstruction and bronchial hyperresponsiveness occurs in patients with bronchiectasis. We conducted a study to assess the efficacy of bronchodilators in the treatment of bronchiectasis. Methodology: Twenty-four patients with confirmed bronchiectasis were studied. Each patient inhaled fenoterol 400 μg administered by metered dose inhaler via a spacer after a baseline lung function and a lung function test was repeated 30 min later. This was followed by a second dose of fenoterol 5 mg via nebulizer and another lung function test 30 min later. A repeat study was done at least 24 h later with ipratropium bromide 40 μg by metered dose inhaler and 500 μg by a nebulizer. Results: The results showed a significant improvement from baselines (mean percentage change ± SD) of peak expiratory flow rate (PEF) by 8.5 ± 8.72% and 15.3 ± 11.63%, forced expiratory volume in 1 s (FEV1) by 8.77 ± 9.69% and 10.2 ± 12.2% and forced vital capacity (FVC) by 10.25 ± 11.61% and 10.09 ± 10.88% after low- and high-dose fenoterol, respectively. The improvements after low- and high-dose ipratropium bromide for PEF, FEV1 and FVC were 9.89 ± 9.35% and 14.39 ± 12.82%, 9.38 ± 10.41% and 13.52 ± 17.09%, and 8.03 ± 10.85% and 9.63 ± 13.85%, respectively. Eleven patients (45.8%) responded to one or both bronchodilators significantly (> 15% improvement in FEV1). Five patients (20%) responded to both, three (12%) to fenoterol alone and another three (12%) to ipratropium bromide alone. Conclusion: There is significant bronchodilator response in a subset of patients with bronchiectasis and patients with bronchiectasis should therefore undergo bronchodilator testing. Skin prick testing against a panel of nine allergens done on each individual yielded a positive result in 13 patients (54.2%). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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