The effects of fenoldopam on renal blood flow and tubular function during aortic cross-clamping in anaesthetized dogs.

Autor: Halpenny, M., Markos, F., Snow, H. M., Duggan, P. F., Gaffney, E., O'connell, D. P., Shorten, G. D.
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Zdroj: European Journal of Anaesthesiology (Cambridge University Press); Aug2000, Vol. 17 Issue 8, p491-498, 8p
Abstrakt: SummaryPostoperative renal impairment is a recognized complication of infrarenal aortic cross-clamping. Fenoldopam, a selective dopamine agonist, may increase renal blood flow and decrease tubular oxygen consumption. The objective of this study was to quantify the effects of fenoldopam (0.1 µg kg-1 min-1) on renal blood flow and renal tubular function in anaesthetized dogs that have undergone aortic cross clamping. Eight labrador dogs were selected to receive either saline or fenoldopam (0.1 µg kg-1 min-1) intravenously. Arterial pressure, heart rate, renal blood flow, urinary output, fractional excretion of sodium, creatinine clearance and lithium clearance were measured (a) prior to infusions of saline or fenoldopam (b) 1 h after commencing the infusion (c) during a 90-min period of infrarenal aortic cross-clamping with concurrent infusion of fenoldopam or saline and (d) for 1 h after simultaneous aortic declamping and discontinuation of the infusions. There was no haemodynamic instability upon commencing the infusion of fenoldopam (0.1 µg kg-1 min-1). Creatinine clearance (2.03 ± 0.5–2.45 ± 0.3 mL min-1 kg-1 (mean ± SD)), urine output (0.23 ± 0.16–0.35 ± 0.23 mL min-1 (mean ± SD)), and fractional excretion of sodium (0.7 ± 0.52–1.3 ± 0.73% (mean ± SD)) increased (P < 0.05), following commencement of the fenoldopam infusion. Fractional excretion of sodium (1.2 ± 0.7% (mean ± SD)) and urine output (0.36 ± 0.21 mL min-1 (mean ± SD)) were maintained during the aortic cross-clamp period (P < 0.05). Renal blood flow increased when the fenoldopam infusion was commenced (145 ± 43.3–161 ± 39.2 mL min-1 (mean ± SD)) and remained greater than baseline during the aortic cross-clamping period (152 ± 44 mL min-1 (mean... [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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