The eosinophilic response and haematological recovery after treatment for Plasmodium falciparum malaria.

Autor:	Camacho, Luis H., Wilairatana, Polarat, Weiss, Günter, Mercader, Marco A., Brittenham, Gary M., Looareesuwan, Sornchai, Gordeuk, Victor R., Camacho, L H, Wilairatana, P, Weiss, G, Mercader, M A, Brittenham, G M, Looareesuwan, S, Gordeuk, V R
Předmět:	PLASMODIUM falciparum EOSINOPHILS HEMOGLOBINS BLOOD testing THERAPEUTICS DRUG therapy for malaria ANTIMALARIALS ANIMAL experimentation COMPARATIVE studies FECES MALARIA RESEARCH methodology MEDICAL cooperation PROTOZOA RESEARCH EVALUATION research RETROSPECTIVE studies NEMATODE infections LEUKOCYTE count DISEASE complications
Zdroj:	Tropical Medicine & International Health; Jul99, Vol. 4 Issue 7, p471-475, 5p, 1 Chart, 2 Graphs
Abstrakt:	To examine a possible relationship between the immune response and haematological recovery after acute falciparum malaria, we followed peripheral blood eosinophil counts and haemoglobin concentrations for 4 weeks after starting effective treatment in 70 adult Thai patients. Eosinophils are induced by Th-2 cytokines as well as other stimuli. Eosinophil counts were elevated in only 8 (11%) of the subjects at presentation, but were increased in 65 (93%) by day 7. Eosinophil counts then decreased markedly by day 14, followed by a second increase until day 28. A significant positive correlation was found between peak eosinophil counts on day 7 and the haemoglobin concentration on day 28, both in 16 subjects without stool parasites (r = 0.65, P = 0.006) and in 54 patients with stool parasites (r = 0.32; P = 0.0019). These results suggest that a robust eosinophilic response shortly after completing antimalarial therapy predicts a good recovery from malaria-associated anaemia. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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