| Autor: |
Julien, Manuel Romano, Gomes, Aurélio, Varandas, Luis, Rodrigues, Paula, Malveiro, Filomena, Aguiar, Pedro, Kolsteren, Patrick, Stuyft, Patrick, Hildebrand, Katherine, Labadarios, Demetre, Ferrinho, Paulo, Julien, M R, Gomes, A, Varandas, L, Rodrigues, P, Malveiro, F, Aguiar, P, Kolsteren, P, Stuyft, P, Hildebrand, K |
| Předmět: |
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| Zdroj: |
Tropical Medicine & International Health; Dec99, Vol. 4 Issue 12, p794-800, 7p, 1 Diagram, 4 Charts |
| Abstrakt: |
Objective: The objective of this study was to test the potential of routine vitamin A supplementation at admission to speed up recovery during hospitalization for acute lower respiratory tract infections (ALRI) and to decrease the levels of morbidity at 6 weeks after discharge. The study was conducted in the Central Hospital of Maputo (CHM), Mozambique, from 1995 to 1997.Methods: Children aged 6-72 months with ALRI admitted to the paediatric wards of the CHM were assigned to a supplementation group (n = 71, receiving 200000 IU of vitamin A) or a control group (n = 93, receiving a placebo).Results: The prevalence of vitamin A deficiency was very high and similar between the two groups. The median number of inpatient days for the supplementation group was 3, for the placebo group 4 days. On day 5 the rate of clinical discharge was 88.4% (n = 61/69) in the experimental intervention group and 73.9% (n = 65/88) in the placebo group (P = 0.023). CONCLUSION We found a statistically significant reduction in duration of admission among vitamin A-supplemented children with ALRI. This effect is in line with what is known about the role of vitamin A in human defence and immune mechanisms and with the serological evidence of the extent of vitamin A deficiency among the children in this trial. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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