| Autor: |
Mockenhaupt, Frank P., Falusi, Adeyinka G., May, Juergen, Ademowo, Olusegun G., Olumese, Peter E., Meyer, Christian G., Bienzle, Ulrich |
| Předmět: |
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| Zdroj: |
Tropical Medicine & International Health; Apr99, Vol. 4 Issue 4, p302, 6p, 3 Charts, 2 Graphs |
| Abstrakt: |
Summary: The proportion to which α-thalassaemia contributes to anaemia in Africa is not well recognized. In an area of intense malaria transmission in South-West Nigeria, haematological parameters of α-thalassaemia were examined in 494 children and 119 adults. The –α[sup 3.7] type of α[sup +]-thalassaemia was observed at a gene frequency of 0.27. Nine and 36.5% of individuals were homozygous and heterozygous, respectively. P.falciparum-infection was present in 78% of children and in 39% of adults. The α-globin genotypes did not correlate with the prevalence of P. falciparum-infection. α[sup +]-thalassaemic individuals had significantly lower mean values of haemoglobin, mean corpuscular volume, and mean corpuscular haemoglobin than non-thalassaemic subjects. Anaemia was seen in 54.7% of children with a normal α-globin genotype, in 69.9% of heterozygous (odds ratio: 1.99, 95% confidence interval: 1.32–3.00, P = 0.001), and in 88.4% of homozygous α[sup +]-thalassaemic children (odds ratio: 7.72, 95% confidence interval: 2.85–20.90, P = 0.0001). The findings show that α[sup +]-thalassaemia contributes essentially to mild anaemia, microcytosis, and hypochromia in Nigeria. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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