| Autor: |
Windmon, Nicole, Dragojlovic, Veljko |
| Předmět: |
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| Zdroj: |
Green Chemistry Letters & Reviews; Sep2008, Vol. 1 Issue 3, p155-163, 9p, 1 Diagram, 1 Chart, 6 Graphs |
| Abstrakt: |
Diels-Alder reactions of neat reactive dienes and dienophiles are frequently vigorous and have a limited preparative value. It is possible to control the temperature of multi-gram scale Diels-Alder reactions by adding a minimal amount of water to neat reactants. In addition, the presence of water resulted in an increased reaction rate and formation of a higher purity product. The use of minimal amounts of other solvents, with lower heat capacities, did not give good results. Furthermore, some dienophiles, e.g. maleic anhydride, reacted poorly in a dilute water suspension or solution, but worked well in the presence of a minimal amount of water. This is an environmentally friendly, practical and efficient approach to preparation of Diels-Alder adducts on a multi-gram scale. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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