Implications of hepatitis C virus infection for behavioral symptoms and activities of daily living.

Autor: Posada, Carolina, Moore, DavidJ., Woods, StevenPaul, Vigil, Ofilio, Ake, Chris, Perry, William, Hassanein, TarekI., Letendre, ScottL., Grant, Igor, the HIV Neurobehavioral Research Center (HNRC) Group
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Zdroj: Journal of Clinical & Experimental Neuropsychology; Jul2010, Vol. 32 Issue 6, p637-644, 8p, 3 Charts, 1 Graph
Abstrakt: Hepatitis C virus (HCV) is neurovirulent and has been shown to be associated with neuropsychological (NP) deficits in a subset of infected individuals. Despite these previous findings, little work has been done to examine neurobehavioral symptoms associated with HCV infection. We examined 34 HCV seropositive (HCV+) individuals and 35 healthy comparison participants (HCV-) with the self-rating form of the Frontal Systems Behavior Scale (FrSBe). Results showed that at the group level, only the FrSBe apathy subscale mean was clinically elevated (T score >65) among HCV+ persons; executive dysfunction, disinhibition, and total subscale means were not clinically elevated. At the individual level, a significantly higher proportion of HCV+ individuals than of HCV- individuals reported clinically elevated FrSBe T scores . Moreover, HCV+ individuals were nearly 3 times as likely to report clinically elevated FrSBe T scores of apathy, executive dysfunction, and disinhibition as compared to HCV- participants. A multiple regression that included substance use disorders, neuropsychological impairment, and age indicated that HCV status was an independent predictor of self-reported FrSBe total T scores. Across all participants, small, yet significant, correlations were found between elevated self-reported FrsBe T scores and dependence in activities of daily living. These results show that a subset of HCV-infected individuals report clinically elevated behavioral symptoms. Clinical implications for the assessment and management of elevated behavioral symptoms in HCV are discussed. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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