| Autor: |
Camba, Lionello, Aldrighetti, Luca, Ciceri, Fabio, Bernardi, Massimo, Marktel, Sarah, Angeli, Enzo, Giacomelli, Maurizio |
| Předmět: |
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| Zdroj: |
British Journal of Haematology; Sep2001, Vol. 114 Issue 3, p638-640, 3p, 1 Graph |
| Abstrakt: |
A 79-year-old patient with post-polycythaemic myelofibrosis presented with severe hypersplenism. After splenic artery catheterization, cytosine arabinoside was given intrasplenically from November 1999 to March 2000 for 5 d/month at 10 mg/m2 and increased each month by 10 mg/m2. It was then administered by continuous infusion until June 2000, starting at 20 mg/m2/d and tapering by 5 mg/m2 every 2 weeks to a final daily dose of 5 mg/m2/d. The drug was then stopped. The spleen had decreased to one third of the initial volume. Clinical conditions and haematological indices improved substantially. Intrasplenic therapy could be a new therapeutic tool for hypersplenism in chronic idiopathic and post-myeloproliferative myelofibrosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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