| Autor: |
Pinkney, J. H., Downs, L., Hopton, M., Mackness, M. I., Bolton, C. H. |
| Předmět: |
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| Zdroj: |
Diabetic Medicine; Dec1999, Vol. 16 Issue 12, p993-999, 7p |
| Abstrakt: |
Summary Aims To examine the hypothesis that increased susceptibility of low density lipoproteins (LDL) to oxidation predisposes to endothelial dysfunction in patients with Type 1 diabetes mellitus. Methods A cross-sectional study of 46 non-nephropathic diabetic and 39 control subjects and in the diabetic patients, a 3-month duration, randomized, placebo-controlled double-blind trial of vitamin E 500 U/day. Flow-mediated vasodilatation (FMD) was measured in the forearm by high resolution ultrasound. LDL oxidation by Cu2 + was measured in vitro. Results Diabetic patients had greater basal and reactive forearm blood flow (geometric mean (sd%) flow (ml/min) 110.15 (19.19%) vs. 74.99 (23.17%); P = 0.045, and 344.35 (20.84%) vs. 205.17 (21.48%); P = 0.007), compared with controls, but there was no difference in FMD (median (interquartile range) 0.00 ( - 0.01–0.02) vs. 0.02 ( - 0.01–0.02) cm2; P = 0.78). Diabetic LDL oxidation lag time correlated with postdilatation brachial artery area (r = 0.32; P = 0.05) but not with FMD. Lag-times and total LDL oxidation by Cu2 + , lipoprotein and vitamin E concentrations were similar in diabetic and control groups. Antibody titres to oxidized LDL (oxLDL) were higher in non-diabetic than diabetic subjects, and were unrelated to FMD. In diabetic patients, vitamin E increased mean (sd) plasma vitamin E levels (24.0 (6.5) to 47.5 (7.5) μmol/l; P = 0.0006) and resulted in increased FMD (Δ 0.00 ( - 0.02–0.01) vs. 0.01 (0.01–0.02)) cm2; P = 0.0036), but no changes in LDL Cu2 + oxidation profiles were observed. Conclusions FMD is no different in Type 1 diabetic and non-diabetic subjects and nor are indices of lipid peroxidation and in vitro LDL oxidation although levels of antibody to oxLDL are lower in... [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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