| Autor: |
Woltering, E.A., Drouant, G.J., Diaco, D.S., Sharma, C., Murphy, W.A., Fuselier, J.A., Coy, D.H., Espenan, G.D., Nelson, J.A., Fisher, D.R., Maloney, T.M., O'Dorisio, M.S., Chen, F., O'Dorisio, T.M. |
| Předmět: |
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| Zdroj: |
Journal of Peptide Research; Feb99, Vol. 53 Issue 2, p201-213, 13p |
| Abstrakt: |
Radio-labeled somatostatin analogs have recently gained popularity as agents useful in intraoperative tumor localization, external scintigraphy and in situ radiotherapy. We have synthesized and characterized a series of novel N-terminally extended multiply-tyrosinated somatostatin analogs that possess high binding affinity for somatostatin receptors, exhibit biological activity comparable to the native peptide and retain these characteristics after iodination. These analogs can be radio-iodinated to high specific activities. Following radio-iodination, these analogs exhibit minimal radiolysis and may be clinically useful for tumor localization, scanning and therapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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