A case of small cerebral cyst and pericentric inversion of chromosome 9 that developed schizophrenia-like psychosis.

Autor: Miyaoka, Tsuyoshi, Seno, Haruo, Itoga, Motoi, Ishino, Hiroshi
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Zdroj: Psychiatry & Clinical Neurosciences; Oct99, Vol. 53 Issue 5, p599-602, 4p
Abstrakt: A case of schizophrenia-like psychosis (psychotic disorder not otherwise specified according to the DSM-IV criteria) with pericentric inversion on chromosome 9 [inv.(9) (p11; q13)] is reported. In this case, a minor brain anomaly, a small cyst in the left subcortex, was observed on magnetic resonance imaging of the brain. In the clinical course, prominent chronic hallucinations were observed; however, there was no evidence of the disorganization of personality, delusion, and deterioration in level of functioning that are usually seen in schizophrenia. This case and a review of the literature indicate that the pericentric region of chromosome 9 might be a potential areas of interest for the aetiology of psychiatric disorders. The phenotype–karyotype relationship of pericentric inversion on chromosome 9 and its relationship to psychosis are discussed. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index