| Autor: |
Nasrin, Collignon, Wilson, Pilotto, Douglas, Nasrin, Nasrin, D, Collignon, P J, Wilson, E J, Pilotto, L S, Douglas, R M |
| Předmět: |
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| Zdroj: |
Journal of Paediatrics & Child Health; Dec1999, Vol. 35 Issue 6, p558-561, 4p |
| Abstrakt: |
Objective: To determine the level of antibiotic resistance in pneumoniae (S. pneumoniae) isolated from nasal swabs of healthy children.Method: Cross-sectional community survey.Setting: Survey was undertaken in general practice settings in Canberra during March and April 1998.Subjects: Four hundred and sixty-one children under 3 years of age enrolled in general practice trial of clinical practice guidelines for antibiotic use.Outcome Measures: Resistance to penicillin, erythromycin, co-trimoxazole, tetracycline, chloramphenicol and cefotaxime among the isolates of S. pneumoniae.Results: A total of 461 nasal swabs were collected and S. pneumoniae was isolated from 171 (37.1%). Penicillin resistance was found in 12.3% of these isolates, with high level resistance in 0.6%. Resistance rates were higher for cotrimoxazole (44.4%) and erythromycin (18.1%) than for penicillin. Multidrug resistance was found in 19% of these isolates. There was a significant association between the attendance at a day care centre and carriage of pneumococcus (53% vs 32%, odds ratio (OR) 2.4, 95% confidence interval (CI) 1.5-3.7, P < 0.001). Children who attended day care centers and had received antibiotics during the 4 months prior to swab collection were three times more likely to carry an antibiotic-resistant isolate than children who had neither attended a day care centre nor received antibiotics (68% vs 40%, OR 3.1, 95% CI 1.2-8.4, P = 0.02).Conclusion: The level of antibiotic resistance in pneumococci from healthy children was of concern. Carriage of pneumococcus was significantly higher in children who attended a day care centre. Resistance was significantly correlated with antibiotic use in combination with day-care attendance. These findings warrant more judicious use of antibiotics in children. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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