Effect of Alcoholic Intoxication on Water Content and Activity of Na,K-ATPase and Ca-ATPase in Rat Brain.

Autor: Zamai, T., Titova, N., Zamai, A., Usol'tseva, O., Yulenkova, O., Shumkova, D.
Zdroj: Bulletin of Experimental Biology & Medicine; Dec2002, Vol. 134 Issue 6, p541-543, 3p
Abstrakt: We studied the effect of 2-week alcohol intoxication on water exchange and activity of Na,K-ATPase and Ca-ATPase in rat brain. Alcohol intoxication increased water content in the brain due to cell hyperhydration. It is assumed that hyperhydration results from increased Na+ content in cells due to inhibition Na,K-ATPase activity, which in turn is caused by activation of lipid peroxidation under the effect of ethanol. A possible mechanism of Na,K-ATPase inhibition. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index