| Autor: |
Kwak, Hye-Min, Jeon, So-Young, Sohng, Bang-Ho, Kim, Jong-Guk, Lee, Jin-Man, Lee, Kyung-Bok, Jeong, Hyun-Hee, Hur, Jong-Moon, Kang, Young-Hwa, Song, Kyung-Sik |
| Zdroj: |
Archives of Pharmacal Research; Dec2005, Vol. 28 Issue 12, p1328-1332, 5p |
| Abstrakt: |
In the course of screening for anti-dementia agents from natural products, two β-secretase (BACE1) inhibitors were isolated from the husk of pomegranate (Punica granatum) by activity-guided purification. They were identified as ellagic acid and punicalagin with IC50 values of 3.9 x10-6 and 4.1x10-7 M and Ki values of 2.4x10-5 and 5.9x10-7 M, respectively. The compounds were non-competitive inhibitors with a substrate in the Dixon plot. Ellagic acid and punicalagin were less inhibitory to α-secretase (TACE) and other serine proteases such as chymotrypsin, trypsin, and elastase, thus indicating that they were relatively specific inhibitors of BACE1. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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