Effects of Acute and Chronic Caffeine Intake on Intravenous Self-Administration of Morphine in Two Rat Strains.

Autor: Sudakov, S., Papazov, I., Lyupina, Yu., Medvedeva, O., Figurina, I., Rusakova, I.
Zdroj: Bulletin of Experimental Biology & Medicine; Oct2002, Vol. 134 Issue 4, p400-402, 3p
Abstrakt: Effects of acute and chronic caffeine intake on the level and pattern of morphine self-administration behavior in WAG/G and Fisher-344 rats were studied. Both acute and chronic caffeine intake decreased morphine self-administration only in WAG/G rats, which attested to increased sensitivity of these rats to reinforcing effects of morphine. Possible relationship between the observed changes and increased anxiety in rats receiving caffeine is discussed. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index