| Autor: |
Kashkin, K., Perevoschikov, A., Nikolaev, A., Turbin, D., Fleischman, E. |
| Zdroj: |
Molecular Biology; May2000, Vol. 34 Issue 3, p337-344, 8p |
| Abstrakt: |
We examined deletions of the short arm of chromosome 1 and aberrations of the microsatellite locus Alu-VpA/MycL1 (1p34.3) in human primary colorectal adenocarcinomas. Cytogenetically discernible deletions in 1p were found in 45% (14/31) of informative tumors. The 1p-tumors commonly exhibited a polyploid karyotype (Fisher P 1=0.023) and a larger number of rearranged chromosomes ( P 2=0.045) versus those without 1p deletions. The 1p deletions often combined with chromosome 5 monosomy (χ2=6.24; p=0.013), chromosome 15 monosomy (χ2=4.20; p=0.040), and 11q deletions ( P 2=0.035). Among the 50 carcinomas, 11 (22%) showed Alu-VpA/MycL1 instability, and 14% (6/43 informative) had lost the Alu-VpA/MycL1 allele. The genetic alterations thus revealed were collated with the clinical and morphological features of the tumors. The loss of the 1p material was shown to be correlated with marked karyotype aberrations in colorectal tumors, and Alu-VpA/MycL1 allele deletions were tightly associated with relapses or metastasis within 30 months after surgery. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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