Characteristics and trends in the incidence of inflammatory bowel disease in Korean children: a single-center experience.

Autor:	Bong Jin Kim, Seung Min Song, Kyung Mo Kim, Yeoun Joo Lee, Kang Won Rhee, Joo Young Jang, Seong Jong Park, Chong Hyun Yoon, Kim, Bong Jin, Song, Seung Min, Kim, Kyung Mo, Lee, Yeoun Joo, Rhee, Kang Won, Jang, Joo Young, Park, Seong Jong, Yoon, Chong Hyun
Předmět:	INFLAMMATORY bowel diseases DISEASE incidence CROHN'S disease in children ULCERATIVE colitis in children ABDOMINAL pain COLITIS FISTULA CROHN'S disease diagnosis INFLAMMATORY bowel disease diagnosis ULCERATIVE colitis diagnosis AGE factors in disease ANALYSIS of variance CHI-squared test CHILDREN'S hospitals COMPARATIVE studies DEMOGRAPHY CROHN'S disease LONGITUDINAL method RESEARCH methodology MEDICAL cooperation NONPARAMETRIC statistics RESEARCH RISK assessment ULCERATIVE colitis EVALUATION research RETROSPECTIVE studies SEVERITY of illness index
Zdroj:	Digestive Diseases & Sciences; Jul2010, Vol. 55 Issue 7, p1989-1995, 7p, 6 Charts, 1 Graph
Abstrakt:	Background: Inflammatory bowel disease (IBD) is rare in Asian children and few reports on pediatric IBD have appeared.Aims: We, therefore, investigated the incidence trends and clinical characteristics of pediatric IBD in Korea.Methods: We enrolled 48 children with Crohn's disease (CD) and 14 children with ulcerative colitis (UC) from 1996 to 2007. Trends in annual enrollment and clinical characteristics were retrospectively evaluated by medical record review.Results: During the 12 years of observation, the number of new enrollments gradually increased. CD showed male predominance (33 boys, 15 girls), but more females presented with UC (4 boys, 10 girls). A relevant family history was observed in 3 (4.9%) of the 61 unrelated families. The most common presenting symptom was abdominal pain (67%) in CD and hematochezia (93%) in UC. Growth delay was observed in 10% of CD patients, but not in any of the UC patients. In CD, colonic involvement occurred in 87% of patients, ileal involvement in 87%, and both the small bowel and colon were affected in 75%. With UC, pancolitis occurred in 43% of patients, left-sided colitis in 36%, and proctitis in 21%, including all three patients with appendiceal orifice inflammation. The most frequent disease behavior was inflammatory in 85% of patients, but perianal fistula was noted in 50% of CD patients.Conclusion: This study showed that the incidence of pediatric IBD has been rapidly increasing in Korea in recent years. Relevant family history is less prevalent and phenotypic expression differs from what is seen in Western countries. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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