| Autor: |
Yumura, Wako, Nitta, Kosaku, Ozu, Hiroyuki, Natori, Kyoko, Eto, Yoko, Kawashima, Akira, Nihei, Hiroshi |
| Zdroj: |
Clinical & Experimental Nephrology; Aug1997, Vol. 1 Issue 3, p212-215, 4p |
| Abstrakt: |
It is not known whether steroid therapy affects the serum level of soluble interleukin-2 receptor (sIL-2R) in patients with glomerulonephritis. We therefore examined the relationship between serum level of sIL-2R and indicators of disease activity in patients with immunoglobulin (Ig) A nephropathy, and serum levels of sIL-2R in patients before and after prednisolone therapy. Serum sIL-2R levels were determined using an immunoenzymatic technique in 97 patients with IgA nephropathy, and the effects of prednisolone therapy on sIL-2R levels were assessed in 15 patients with IgA nephropathy. An increased level of serum sIL-2R was shown at the time of renal biopsy in all patients with IgA nephropathy. Moreover, the serum sIL-2R levels were positively correlated with urinary protein excretion ( P<0.01, r=0.32) and negatively correlated with creatinine clearance ( P<0.01, r=−0.42) in all patients with IgA nephropathy. Prednisolone therapy (0.8 mg/kg per day) caused a significant reduction in the serum sIL-2R level in accordance with the decrease in daily proteinuria in 15 patients with IgA nephropathy. These results suggest that the measurement of serum sIL-2R would be useful in evaluating the degree of disease activity, and the serum sIL-2R levels may be a useful indicator for estimating the effect of prednisolone therapy in patients with IgA nephropathy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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