| Autor: |
Tolmacheva, I. A., Igosheva, E. V., Grishko, V. V., Zhukova, O. S., Gerasimova, G. K. |
| Předmět: |
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| Zdroj: |
Russian Journal of Bioorganic Chemistry; May2010, Vol. 36 Issue 3, p377-382, 6p, 3 Diagrams, 1 Chart |
| Abstrakt: |
Novel 2,3- seco-triterpenic amides were prepared by the interaction of the chloride of 1-cyano-19β,28-epoxy-18α-oleane-3-oic acid with primary amines and synthetic and biogenic amino acids. A cytotoxic triterpenic conjugate with a residue of the ethyl ester of β-alanine was found among the synthesized nitrogen-containing derivatives. Treatment with this conjugate in a concentration of 100 μM resulted in the 45.5% survival of melanoma cells in the medium. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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